Status:
NOT_YET_RECRUITING
Using Platelet-rich Fibrin in Regenerative Endodontic Treatment in Mature Permanent Teeth
Lead Sponsor:
University of Medicine and Pharmacy at Ho Chi Minh City
Collaborating Sponsors:
Odonto-Maxillo Facial Hospital in Ho Chi Minh City
Conditions:
Chronic Apical Periodontitis
Necrosis of Pulp
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
This study aims to evaluate the antibacterial effects of injectable platelet-rich fibrin (i-PRF) in vitro, and to assess the clinical and radiographic outcomes of using advanced platelet-rich fibrin (...
Detailed Description
This study aims to evaluate the antibacterial effects of injectable platelet-rich fibrin (i-PRF) in vitro, and to assess the clinical and radiographic outcomes of using advanced platelet-rich fibrin (...
Eligibility Criteria
Inclusion
- Participants had a single-rooted tooth with necrotic pulp (negative response to electric pulp testing), with or without periapical pathology (acute apical periodontitis of pulpal origin, chronic periapical periodontitis, periapical abscess with sinus, periapical abscess without sinus), and gave their consent to participate in the study.
Exclusion
- Study samples will be excluded if any of the following criteria are met:
- The tooth has had previous endodontic treatment.
- The root apex is not fully developed, or there is root resorption/cracking/fracture.
- The tooth has severe tooth loss and is indicated for extraction, or is indicated for restoration with a post or cast core after endodontic treatment.
- The root canal is calcified.
- The root canal curvature is greater than 25º.
- The tooth has a periapical cyst or is associated with a jawbone cyst.
- The tooth has a periodontal pocket deeper than 4 mm.
- The tooth has no occlusal contact.
- The patient is pregnant.
- The patient has diabetes or HIV or other immunocompromised conditions.
Key Trial Info
Start Date :
September 15 2025
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
August 31 2027
Estimated Enrollment :
57 Patients enrolled
Trial Details
Trial ID
NCT07192289
Start Date
September 15 2025
End Date
August 31 2027
Last Update
September 25 2025
Active Locations (1)
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1
Odonto-Maxillo-Facial Hospital and University of Medicine and Pharmacy at Ho Chi Minh City
Ho Chi Minh City, Ho Chi Minh City, Vietnam, 70000