Status:
NOT_YET_RECRUITING
Perioperative GDNF as a Predictive Factor for Postoperative Delirium and Adverse Neurological Outcomes in Pediatric Surgery
Lead Sponsor:
General Hospital of Ningxia Medical University
Conditions:
Postoperative Cognitive Dysfunction
Postoperative Delirium
Eligibility:
All Genders
1-3 years
Phase:
NA
Brief Summary
To observe the dynamic changes in serum levels of inflammatory cytokines (e.g., IL-6, TNF-α), Brain-Derived Neurotrophic Factor (BDNF), and Glial Cell Line-Derived Neurotrophic Factor (GDNF) during th...
Detailed Description
Clarify the Correlation Between Perioperative Changes in Inflammatory Factors, BDNF, and GDNF Levels and Postoperative delirium (POD) Blood and urine samples were collected from pediatric patients at ...
Eligibility Criteria
Inclusion
- (1) Aged 1-3 years; (2) American Society of Anesthesiologists (ASA) Physical Status Classification I-II; (3) Body Mass Index (BMI) 18-35 kg/m²; (4) Agreement to participate in the study and signed informed consent form.
Exclusion
- (1) Surgical duration exceeding 4 hours; (2) Patients with language or hearing impairments hindering effective communication; (3) Patients with postoperative infections or perioperative cardiopulmonary complications; (4) Patients with preoperative psychiatric disorders.
Key Trial Info
Start Date :
September 15 2025
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
December 1 2030
Estimated Enrollment :
200 Patients enrolled
Trial Details
Trial ID
NCT07192549
Start Date
September 15 2025
End Date
December 1 2030
Last Update
September 25 2025
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