Status:
NOT_YET_RECRUITING
ESD in Locally Advanced Rectal Cancer Following CRT
Lead Sponsor:
Assiut University
Conditions:
Rectal Cancer
Eligibility:
All Genders
18+ years
Brief Summary
residual mucosal lesions in patients with locally advanced rectal cancer after CRT are still confusing for decision to continue follow up or excise. Investigators decided to compare two groups with c...
Detailed Description
Colorectal cancer (CRC) represents a significant health challenge in Egypt. According to GLOBOCAN 2020, rectal cancer ranks sixth in all cancers among males and females, with 5,231 new cases, accounti...
Eligibility Criteria
Inclusion
- Adult patients with rectal adenocarcinoma who underwent full course locoregional chemoradiotherapy with organ-preservation intent.
- Post-CRT assessment showing either:
- A. Small residual mucosal/submucosal lesion amenable to en-bloc ESD (CRT→ESD), OR B. Clinical/radiologic near-complete/complete response and decision to observe (CRT→Follow-up).
Exclusion
- \- Evidence of distant metastasis at post-CRT restaging.
- Lesions unsuitable for endoscopic resection (circumferential, deeply invasive on EUS/MRI).
- Patients who had immediate TME after CRT for other reasons.
- Unfit for endoscopy or follow-up.
Key Trial Info
Start Date :
October 1 2025
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
September 30 2028
Estimated Enrollment :
20 Patients enrolled
Trial Details
Trial ID
NCT07192627
Start Date
October 1 2025
End Date
September 30 2028
Last Update
September 25 2025
Active Locations (1)
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1
Assiut University
Asyut, Egypt, 71515