Status:
ACTIVE_NOT_RECRUITING
Pleural Fluid Neutrophil Extracellular Traps Exacerbate Disease Severity and Risk of One-year Mortality in Pleural Infection (TORPIDS-3)
Lead Sponsor:
University of Oxford
Collaborating Sponsors:
University of Dundee
Conditions:
Pleural Infection
Eligibility:
All Genders
18+ years
Brief Summary
Pleural infection is a severe and complicated disease which is associated with significant morbidity and mortality. People with pleural infection show diverse levels of neutrophil degranulation activi...
Eligibility Criteria
Inclusion
- Inclusion Criteria:
- Patients were included if they had a clinical presentation consistent with pleural infection as stated in the Methods section of the main manuscript and any of the following criteria:
- Pleural fluid that was macroscopically purulent, OR
- Pleural fluid that was positive on culture for bacterial infection, OR
- Pleural fluid that demonstrated bacteria on Gram staining, OR
- Pleural fluid with pH ≤7.2 (measured in a blood gas analyser) or low glucose level (≤3mmol/L or ≤55mg/dL) in a patient with clinical evidence of infection, OR
- Contrast-enhanced CT evidence of pleural infection (consolidation of underlying lung with enhancing pleural collection) in a patient with clinical evidence of infection, alongside exclusion of other sources of infection.
- Exclusion criteria:
- Age less than 18 years, OR
- No pleural fluid available for analysis, OR
- Patient previous pneumonectomy on the side of pleural infection, OR
- Expected survival less than three months due to co-morbid disease, as judged by the recruiting physician
Exclusion
Key Trial Info
Start Date :
January 9 2024
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
October 1 2025
Estimated Enrollment :
326 Patients enrolled
Trial Details
Trial ID
NCT07194915
Start Date
January 9 2024
End Date
October 1 2025
Last Update
September 26 2025
Active Locations (1)
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1
CAMS Oxford Institute, Nuffield Department of Medicine
Oxford, United Kingdom