Status:
NOT_YET_RECRUITING
Effects of Surgical, Percutaneous or Medical Treatments for Coronary Artery Disease on Renal Function: Long-Term Outcome. Cardiorenal-trial.
Lead Sponsor:
Instituto do Coracao
Conditions:
Coronary Artery Disease
Chronic Kidney Disease
Eligibility:
All Genders
Brief Summary
Background: Coronary artery disease (CAD) is treated with coronary artery bypass grafting (CABG), percutaneous coronary intervention (PCI), or optimized medical therapy (OMT). Their cardiovascular out...
Detailed Description
Background: Coronary artery disease (CAD) treatment strategies-coronary artery bypass grafting (CABG), percutaneous coronary intervention (PCI), or optimized medical therapy (OMT)-have well-establishe...
Eligibility Criteria
Inclusion
- Multivessel coronary artery disease (CAD) documented by angiography (2 or more epicardial arteries with stenosis of 70% or more);
- Preserved left ventricular systolic function;
- Have undergone treatment with medical therapy (MT), coronary artery bypass graft (CABG) or percutaneous coronary artery intervention (PCI), using drug-eluting stents (DES) or bare-metal stents (BMS);
- Availability of baseline serum creatinine values at the time of enrollment;
- Availability of serum creatinine measurements for a minimum of five years.
Exclusion
- Presence of acute coronary syndrome at baseline;
- Limited life expectancy due to noncardiac comorbidities;
- Inability to maintain regular outpatient follow-up;
- Significant left main coronary artery disease (stenosis greater than 50%);
- Advanced chronic kidney disease (estimated glomerular filtration rate \[eGFR\] less than 30mL/min/1,73m2);
- End-stage renal disease requiring dialysis or history of kidney transplantation.
Key Trial Info
Start Date :
October 1 2025
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
December 1 2028
Estimated Enrollment :
1700 Patients enrolled
Trial Details
Trial ID
NCT07195747
Start Date
October 1 2025
End Date
December 1 2028
Last Update
September 29 2025
Active Locations (1)
Enter a location and click search to find clinical trials sorted by distance.
1
Instituto do Coração (InCor) do Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo (HCFMUSP)
São Paulo, São Paulo, Brazil, 05403-900