Status:
NOT_YET_RECRUITING
Regenerative Potentials of Mature Mandibular Molars With Symptomatic Irreversible Pulpitis Enhanced With Different Scaffolds
Lead Sponsor:
Cairo University
Conditions:
Symptomatic Irreversible Pulpitis (SIP)
Eligibility:
All Genders
15-40 years
Phase:
NA
Brief Summary
The current study aims to assess the influence of different scaffolds on postoperative pain and success rate of pulpotomy in mandibular mature molars with symptomatic irreversible pulpitis
Detailed Description
The study aims to assess different scaffolds used in regenerative pulpotomy of mature permanent mandibular first molars diagnosed with symptomatic irreversible pulpitis and their influence on postoper...
Eligibility Criteria
Inclusion
- ASA I patients who are free from any physical or mental handicapping condition with no underlying systemic disease.
- Age between 15-40 years.
- Males \& Females.
- Patients' acceptance to participate in the trial.
- Patients who can understand pain scale and can sign the informed consent (Appendix I).
- Mature mandibular fist molars:
- Diagnosed clinically with symptomatic irreversible pulpitis and normal periapical tissue.
- Giving a positive response to pulp sensitivity testing.
- Having negative response to percussion.
- Having normal radiographic appearance of periapical tissues.
- Having bright red color of pulp tissue, with hemorrhage control within 10 mins, upon access cavity preparation.
Exclusion
- Pregnant and lactating females.
- Patients with physical or mental handicapping conditions.
- Patients unwilling to participate in a 12-months follow up.
- Mandibular first molars with:
- Immature roots.
- Negative response to pulp sensitivity testing.
- Positive response to percussion.
- Radiographic evidence of periapical lesions, external or internal root resorption, vertical root fracture, or calcification.
- Intraoral swelling or fistula.
- Lack of pulpal bleeding, or inability to achieve hemostasis of the bleeding pulp within 10 mins, upon access cavity preparation.
Key Trial Info
Start Date :
November 1 2025
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
November 1 2027
Estimated Enrollment :
75 Patients enrolled
Trial Details
Trial ID
NCT07196683
Start Date
November 1 2025
End Date
November 1 2027
Last Update
October 2 2025
Active Locations (1)
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1
Faculty of Dentistry, Cairo University
Cairo, Egypt