Status:
RECRUITING
Repetitive Transcranial Magnetic Stimulation Primed Self-controlled Practice on Motor Learning
Lead Sponsor:
National Taiwan University Hospital
Collaborating Sponsors:
National Science and Technology Council, R.O.C.
Conditions:
rTMS Stimulation
Autonomy
Eligibility:
All Genders
18-35 years
Phase:
NA
Brief Summary
This study aims to investigate the additive effects of combining self-controlled practice with repetitive transcranial magnetic stimulation (rTMS) pretreatment on motivation enhancement and motor lear...
Eligibility Criteria
Inclusion
- Healthy adults aged 18-35 years
- Right-handed (per Edinburgh Handedness Inventory)
- Normal or corrected-to-normal vision and hearing
- Eligible for non-invasive brain stimulation per safety screening (no contraindications to TMS)
- Able to understand study procedures and provide written informed consent in Chinese
- Willing to comply with all study visits and tasks, including TBS/rTMS and motor practice
- For yoked pairing: able to be matched to a counterpart participant for practice parameters
Exclusion
- History of epilepsy, seizures, or unexplained fainting; family history of epilepsy in first-degree relatives
- Any intracranial metal or implanted medical devices (e.g., cochlear implant, deep brain stimulator, aneurysm clips); non-removable metallic objects in head/neck
- Cardiac pacemaker or other implanted electronic devices
- Current or past major neurological or psychiatric disorders (e.g., stroke, traumatic brain injury, multiple sclerosis, major depression, bipolar disorder, schizophrenia)
- Current use of medications lowering seizure threshold or affecting cortical excitability (e.g., tricyclic antidepressants, bupropion, clozapine, lithium, stimulant or sedative-hypnotic abuse); or unstable psychotropic regimens
- Active migraine with aura or chronic severe headaches
- Pregnancy or planning pregnancy during participation; breastfeeding (if your site policy excludes)
- Substance or alcohol use disorder within the past 12 months; positive alcohol/drug screen on visit days
- Sleep deprivation (\<5 hours) on the day before stimulation, or excessive caffeine (\>400 mg) within 6 hours pre-stimulation
- Dermatologic conditions or open wounds at stimulation or EMG/electrode sites
- Prior extensive training on the specific motor task used in this study (risk of ceiling effects)
- Concurrent participation in another interventional study or received brain stimulation (TMS/tDCS) within the past 3 months
- Any condition that, in the investigator's judgment, makes participation unsafe or data unreliable
Key Trial Info
Start Date :
September 1 2025
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
December 31 2028
Estimated Enrollment :
72 Patients enrolled
Trial Details
Trial ID
NCT07197346
Start Date
September 1 2025
End Date
December 31 2028
Last Update
September 29 2025
Active Locations (1)
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1
National Taiwan University Hospital
Taipei, Taiwan, 100