Status:
NOT_YET_RECRUITING
2-HOBA Supplementation in People With Elevated Lipoprotein(a)
Lead Sponsor:
The Miriam Hospital
Conditions:
Hyperlipidemia
Elevated Lp(a)
Eligibility:
All Genders
18-69 years
Phase:
NA
Brief Summary
The goal of this clinical trial is to learn if a natural supplement called 2-hydroxybenzylamine (2-HOBA) can reduce harmful oxidized lipids and improve the function of lipoprotein(a) in adults with hi...
Detailed Description
Lipoprotein(a), or Lp(a), is a genetically determined cholesterol particle that increases the risk of heart disease and stroke. High levels of Lp(a) affect about 1 in 4 people, and there are no approv...
Eligibility Criteria
Inclusion
- Males and females aged 18-69 years.
- Elevated Lp(a) levels ≥ 90 mg/dL.
- Able to provide informed consent and adhere to study schedules.
- Willing to follow a physician-recommended diet during the study.
Exclusion
- Pregnant, planning pregnancy during the study period, or currently breastfeeding.
- Individuals with established cardiovascular disease
- Planning major changes in diet or exercise routines.
- Experienced \>20% weight change in the past 3 months.
- Diagnosed with malabsorption syndrome or chronic diarrhea.
- Abnormal liver, kidney, or thyroid function.
- Drug or alcohol abuse within the past 6 months, or significant mental/psychological impairment.
- Have known bleeding disorders (e.g., hemophilia).
- Planned surgery during the study period.
- Donated blood within the last 2 weeks or planning to donate during the study.
- Require regular blood transfusions.
Key Trial Info
Start Date :
November 1 2025
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
November 1 2026
Estimated Enrollment :
10 Patients enrolled
Trial Details
Trial ID
NCT07198009
Start Date
November 1 2025
End Date
November 1 2026
Last Update
September 30 2025
Active Locations (1)
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1
Lipid Clinic at Brown University Health
Providence, Rhode Island, United States, 02914