Status:
RECRUITING
Duodenal Polyposis Classification in FAP
Lead Sponsor:
Fondazione IRCCS Istituto Nazionale dei Tumori, Milano
Collaborating Sponsors:
IRCCS Ospedale San Raffaele
Conditions:
Duodenum Cancer
Familial Adenomatous Polyposis
Eligibility:
All Genders
18+ years
Brief Summary
Duodenal cancer is the leading cause of cancer-related mortality in patients with familial adenomatous polyposis (FAP), yet the current Spigelman staging system provides limited predictive accuracy fo...
Detailed Description
Duodenal cancers represent the leading cause of cancer-related mortality in individuals with familial adenomatous polyposis (FAP). While endoscopic surveillance is a critical component of duodenal can...
Eligibility Criteria
Inclusion
- Confirmed germline diagnosis of FAP, as defined by genetic testing
- Two or more upper gastrointestinal endoscopies
- Complete documentation of all Spigelman classification variables at each endoscopic evaluation
Exclusion
- Histological grading of duodenal polyps incomplete
- Follow-up data were unavailable
- Duodenal surgery before study baseline endoscopy
Key Trial Info
Start Date :
February 2 2018
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
January 15 2030
Estimated Enrollment :
300 Patients enrolled
Trial Details
Trial ID
NCT07199127
Start Date
February 2 2018
End Date
January 15 2030
Last Update
September 30 2025
Active Locations (2)
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1
IRCCS Ospedale San Raffaele
Milan, MI, Italy, 20129
2
Fondazione IRCCS Istituto Nazionale dei Tumori
Milan, Italy, 20133