Status:
NOT_YET_RECRUITING
Quantifying Multi-step Avoidance in Anxiety
Lead Sponsor:
Emory University
Collaborating Sponsors:
National Institute of Mental Health (NIMH)
Conditions:
Anxiety
Anxiety Disorders
Eligibility:
All Genders
22-55 years
Brief Summary
This study aims to learn more about avoidance behavior in people with anxiety, using mathematical models of decision-making processes and decoded neural signals of threat imminence. Researchers are i...
Detailed Description
Current learning theories of anxiety propose that disrupted fear learning underlie anxiety disorders. This suggests that treatments like exposure therapy work by changing learned threat values. Howeve...
Eligibility Criteria
Inclusion
- Ability to comprehend written and spoken English
- Ability to provide informed consent
- Estimated intelligence quotient (IQ) \>70.
- Clinically significant anxiety symptoms (scoring above clinical cutoff on at least one Inventory of Depression and Anxiety Symptoms (IDAS) anxiety-related subscale and/or OASIS total)
- Significant anxiety-related avoidance (scoring 2 or above on a 0-4 scale, indicating at least "occasional" avoidance) on the avoidance-related question on the Overall Anxiety Severity and Impairment Scale (OASIS)
- Functional impairment, defined as at least moderate impairment in one WHO Disability Assessment Schedule (WHODAS 2.0) domain related to anxiety.
Exclusion
- Individuals younger than 22 or older than 55,
- Individuals with an IQ \< 70,
- A lifetime history of neurological disorder or brain damage,
- Contraindications for undergoing MRI scanning,
- A lifetime history or diagnosis of psychosis or bipolar disorder,
- Current substance use intoxication or withdrawal,
- Severe risk of suicide, or
- Recent (\<3 months) changes in psychotropic medicine or psychotherapy treatment,
- Ineligible at the PI's discretion, are excluded.
Key Trial Info
Start Date :
January 1 2027
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
June 1 2030
Estimated Enrollment :
163 Patients enrolled
Trial Details
Trial ID
NCT07203027
Start Date
January 1 2027
End Date
June 1 2030
Last Update
October 2 2025
Active Locations (2)
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1
Emory College
Atlanta, Georgia, United States, 30322
2
Facility for Education and Research in Neuroscience (FERN)
Atlanta, Georgia, United States, 30322