Status:
NOT_YET_RECRUITING
The Role of Janus Kinase (JAK) and Voltage-gated Sodium Channels (Nav) on Pain and Itch
Lead Sponsor:
Aalborg University
Conditions:
Itchiness
Eligibility:
All Genders
18-60 years
Phase:
NA
Brief Summary
It is well known that itch and pain have many communalities in terms of pathways and molecules involved. Therefore, it is very important to investi-gate different substances that work against both pai...
Eligibility Criteria
Inclusion
- Healthy men and women
- 18-60 years
- Speak and understand English
Exclusion
- Pregnancy or lactation
- Drug addiction defined as any use of cannabis, opioids, or other drugs that may cause addiction.
- Previous or current history of neurological, dermatological (e.g., AD, psoriasis, etc.), immunological, musculoskeletal, cardiac disorder or psychiatric diagnoses that may affect the results (e.g., neuropathy, muscular pain in the upper extremities, anxiety, depression, schizophrenia, etc.)
- Moles, wounds, scars, or tattoos in the area to be treated or tested
- Current use of medications that may affect the trial such as antihistamines and painkillers
- use of antihistamines should be discontinued 72 hours before the experiment and all topical agents and emollients should be discontinued 24 hours before the experiment).
- Use of systemic and topical corticosteroids
- Previous traumatic experience of an electrical accident
- Application of moisturizing lotion of the volar site of the forearms (24 hours before study start)
- Skin diseases
- Consumption of alcohol or painkillers 24 hours before the study days and between these
- Acute or chronic pain and itch
- Known allergy/intolerance to lidocaine/phenytoin/mepyramine
- Participation in other trials within 1 week of study entry (4 weeks in the case of pharmaceutical studies)
- Lack of ability to cooperate
Key Trial Info
Start Date :
December 1 2025
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
December 31 2026
Estimated Enrollment :
30 Patients enrolled
Trial Details
Trial ID
NCT07203274
Start Date
December 1 2025
End Date
December 31 2026
Last Update
November 21 2025
Active Locations (1)
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1
Center for Neuroplasticity and Pain Faculty of Medicine, Aalborg University Selma Lagerløfs Vej 249 9260 Gistrup, Denmark
Gistrup, Denmark, 9260