Status:
ENROLLING_BY_INVITATION
Efficacy and Safety of Prophylactic Antibiotics in Preventing Ventilator-associated Pneumonia: A Randomized, Double Blind, Placebo-controlled Trial
Lead Sponsor:
Esraa Salah Mohamed Abdallah Eladl
Conditions:
Ventilator-Associated Pneumonia (VAP)
Eligibility:
All Genders
18-70 years
Phase:
NA
Brief Summary
Evaluate efficacy and safety of prophylactic antibiotics in preventing early ventilator-associated pneumonia
Eligibility Criteria
Inclusion
- • Age \> 18 years or older
- Both sexes will be included.
- Invasive mechanical ventilation
Exclusion
- ongoing pneumonia or gross aspiration confirmed by the presence of lung infiltrates on chest radiographs at admission before invasive ventilation
- previous lung disease precluding accurate interpretation of chest radiographs
- ongoing antibiotic therapy or during the week before admission
- known chronic colonization with multidrug-resistant bacteria
- known allergy to beta-lactam antibiotics
- Pregnancy
Key Trial Info
Start Date :
November 1 2024
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
November 1 2025
Estimated Enrollment :
100 Patients enrolled
Trial Details
Trial ID
NCT07203638
Start Date
November 1 2024
End Date
November 1 2025
Last Update
October 2 2025
Active Locations (1)
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1
Benha university hospital
Banhā, Al-Qalyubia, Egypt, 13511