Status:
RECRUITING
Evaluation of the Link Between Carotid Arterial Wall Viscosity and Major Neurocognitive Disorders
Lead Sponsor:
University Hospital, Rouen
Conditions:
Neurocognitive Disorders
Alzheimer's Disease
Eligibility:
All Genders
70+ years
Brief Summary
The mechanical behavior of conductance arteries is viscoelastic. While the elastic component has been extensively studied, the viscous component has often been neglected for methodological reasons and...
Detailed Description
Preliminary work in the laboratories has highlighted the role of vaso-relaxing endothelial factors and smooth muscle tone in the regulation of the Arterial Pulse Rate (APR) of the radial artery in the...
Eligibility Criteria
Inclusion
- Age over 70
- Memory consultation consultant (neurology or geriatrics)
- Brain MRI less than one year old or planned as part of the cognitive assessment performed.
- Patient diagnosed with Alzheimer's disease according to DSM-5 criteria or vascular dementia according to DSM-5 criteria, or presenting a memory complaint without evidence of a dementia-related condition.
- No objection from the patient or their caregiver.
- Patient covered by a health insurance plan
Exclusion
- Known unilateral or bilateral carotid stenosis or history of carotid surgery
- Permanent CA/AF
- Patient presenting with confusion
- Known psychiatric illness (severe depression, psychosis, etc.)
- Non-vascular, non-Alzheimer's dementia (e.g., Lewy Body Dementia, Parkinsonian Dementia, Progressive Supranuclear Palsy)
- Refusal to participate
- MMS less than or equal to 10
- Contraindication to performing an MRI
- Any acute decompensated pathology
- Patient under guardianship or curatorship
Key Trial Info
Start Date :
February 15 2022
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
September 18 2026
Estimated Enrollment :
140 Patients enrolled
Trial Details
Trial ID
NCT07205003
Start Date
February 15 2022
End Date
September 18 2026
Last Update
October 3 2025
Active Locations (1)
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1
University Rouen Hospital
Rouen, France, 76031