Status:
NOT_YET_RECRUITING
Restructuring the Alpha-Gamma Code in Aging Vision
Lead Sponsor:
Boston University Charles River Campus
Conditions:
Aging
Visual Perception
Eligibility:
All Genders
18+ years
Phase:
EARLY_PHASE1
Brief Summary
Tests whether age-related visual deficits arise from disrupted alpha-gamma coupling in visual cortex (V1) and MT. Uses fMRI, source-resolved HD-EEG, and personalized complex-waveform HD-tACS to (1) qu...
Detailed Description
The project probes a causal account of age-related perceptual decline by focusing on alpha-gamma phase-amplitude coupling (PAC) in early visual cortex and area MT. The central hypothesis is that aging...
Eligibility Criteria
Inclusion
- 18+ years of age or older
- normal or corrected-to-normal visual acuity, color vision, and stereo vision
Exclusion
- not pregnant,
- no metal implants in head,
- no implanted electronic devices,
- no history of neurological problems or head injury,
- no skin sensitivity,
- no claustrophobia,
- no dementia (normal Mini Mental State Examination between 24-30; Montreal Cognitive Assessment \> 25)
- no depression (normal Beck Depression Inventory II \<13; Geriatric Depression Scale \< 10)
- no ophthalmological diseases (e.g., strabismus, glaucoma, cataract, macular degeneration)
- no history of psychosis
- no cognitive deficits (MMSE score\>24; MoCA\>25)
- cannot be taking any psychoactive medication.
Key Trial Info
Start Date :
January 10 2026
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
August 31 2030
Estimated Enrollment :
240 Patients enrolled
Trial Details
Trial ID
NCT07208318
Start Date
January 10 2026
End Date
August 31 2030
Last Update
October 6 2025
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