Status:
NOT_YET_RECRUITING
Endocrine Dysfunction in Pediatric Wilson's Disease
Lead Sponsor:
Assiut University
Conditions:
Wilson's Disease
Eligibility:
All Genders
3-18 years
Brief Summary
This cross-sectional study investigates endocrine changes in children diagnosed with Wilson's disease, aiming to characterize hormonal dysfunctions affecting pituitary, thyroid, adrenal, and gonadal a...
Detailed Description
Wilson's disease (WD) is an inherited copper metabolism disorder leading to copper accumulation in various organs including endocrine glands. While hepatic and neurological effects are well-documented...
Eligibility Criteria
Inclusion
- Children aged 3-18 years
- Confirmed diagnosis of Wilson's disease (based on clinical features, biochemical markers such as serum ceruloplasmin and 24-hour urinary copper)
- Both newly diagnosed and treated patients (chelation/zinc therapy)
- Informed consent from parents or guardians
Exclusion
- Congenital or acquired endocrine disorders unrelated to WD (e.g., congenital hypothyroidism, pituitary tumors)
- Concurrent use of medications affecting hormonal function unless prescribed for WD (steroids, thyroid replacements, contraceptives)
- Chronic systemic illnesses that confound endocrine assessment (e.g., malignancy, chronic renal failure)
Key Trial Info
Start Date :
June 30 2026
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
December 30 2027
Estimated Enrollment :
30 Patients enrolled
Trial Details
Trial ID
NCT07208565
Start Date
June 30 2026
End Date
December 30 2027
Last Update
October 6 2025
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