Status:
RECRUITING
Pre-emptive Endoscopic Vacuum Therapy Reduces the Incidence of Anastomotic Leakage After Colorectal Cancer Surgery: a Randomized Controlled Study
Lead Sponsor:
Nanchong Central Hospital
Conditions:
Colorectal Cancer
Colorectal Surgery
Eligibility:
All Genders
18-85 years
Phase:
NA
Brief Summary
Evaluate the safety and efficacy of postoperative Pre-emptive EVT (PEVT) in reducing the incidence of anastomotic leaks within 30 days after surgery in patients with colorectal cancer. Compare the dif...
Eligibility Criteria
Inclusion
- Pathologically diagnosed with colorectal cancer, planned for radical surgery (right hemicolectomy, left hemicolectomy, or anterior resection of the rectum, etc.).
- Age 18-85 years, American Society of Anesthesiologists (ASA) classification I-III.
- Anastomosis to be performed in a single stage (meeting anastomotic criteria).
- Patient or legal guardian is able to understand and sign the informed consent form and comply with follow-up.
Exclusion
- Preexisting anastomotic leakage or severe intra-abdominal infection before surgery.
- Complicated by severe cardiovascular or cerebrovascular diseases (e.g., acute myocardial infarction, acute phase of cerebral infarction).
- Severe liver or kidney dysfunction (liver function Child-Pugh class C, creatinine clearance \<30 ml/min).
- Coagulation disorders (platelets \<50×10⁹/L, INR \>1.5) or receiving anticoagulant therapy that cannot be adjusted.
- History of abdominal radiotherapy or multiple abdominal surgeries leading to severe intra-abdominal adhesions.
- Complicated by other malignant tumors and currently undergoing radiotherapy or chemotherapy.
- Psychiatric illness or cognitive impairment preventing compliance with the study.
Key Trial Info
Start Date :
September 22 2025
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
December 30 2026
Estimated Enrollment :
110 Patients enrolled
Trial Details
Trial ID
NCT07208786
Start Date
September 22 2025
End Date
December 30 2026
Last Update
October 6 2025
Active Locations (1)
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1
Nanchong Central Hospital
Nanchong, Sichuan, China, 637000