Status:
NOT_YET_RECRUITING
The Effect of Near-infrared Light Therapy on Brain Function and Cognition in Young and Older Adults
Lead Sponsor:
University of Oklahoma
Conditions:
Cognition
Neurovascular Coupling Mechanism and Cognitive Function
Eligibility:
All Genders
21-85 years
Phase:
NA
Brief Summary
The goal of this pilot clinical trial is to test whether transcranial photobiomodulation (tPBM), a non-invasive brain stimulation technique using near-infrared light, can improve brain blood flow regu...
Detailed Description
Cognitive decline is a major cause of disability in older adults, and vascular pathologies play a critical role in the genesis of age-related cognitive impairment. Despite advances in understanding th...
Eligibility Criteria
Inclusion
- Age: 21-85 years of age
- Adequate hearing and visual acuity to participate in the examinations
- Ability to read and write in English
- Competence to provide informed consent
Exclusion
- Active CNS disease including multiple sclerosis, uncontrolled seizures, active brain cancer
- Cerebrovascular accident other than TIA within 60 days prior to Visit 0
- Major psychiatric disease, including major depression not currently controlled on medications, alcohol or drug abuse
- Participant currently uses commercial brain stimulation / neuromodulation device or an experimental device as part of a research study, e.g. tDCS, tACS, TBS, DBS, TMS, TPBM, etc.
- Participant currently takes dietary supplements with an expected cerebrovascular benefit, such as NAD- or NR-supplementum, L-citrullin, urolithin
- Unstable medical condition, including uncontrolled diabetes, chronic heart issues, heart failure, chronic obstructive pulmonary disease, Stage 2 hypertension uncontrolled by medication (\>160/100 mmHg)
- Any other medical condition or medication which, in the opinion of investigator, would render the patient inappropriate or too unstable to complete the study protocol.
- Pregnancy or trying to become pregnant in the next 1 months (self-reported), breastfeeding
Key Trial Info
Start Date :
September 29 2025
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
December 31 2026
Estimated Enrollment :
30 Patients enrolled
Trial Details
Trial ID
NCT07209683
Start Date
September 29 2025
End Date
December 31 2026
Last Update
October 7 2025
Active Locations (1)
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1
University of Oklahoma Health Campus
Oklahoma City, Oklahoma, United States, 73104