Status:
NOT_YET_RECRUITING
Collagenase Biobank Study
Lead Sponsor:
University of Chicago
Collaborating Sponsors:
University of California, San Diego
Midwestern University
Conditions:
Colorectal (Colon or Rectal) Cancer
Eligibility:
All Genders
18+ years
Brief Summary
The purpose of this study is to look at how bacteria present within the stool at the time of surgery and postoperatively may contribute to the development of cancer recurrence after surgery. By collec...
Detailed Description
The purpose of this study is to collect stool, blood, and tissue samples both before and after patients undergo surgery for colon cancer. These samples will be analyzed for their bacterial composition...
Eligibility Criteria
Inclusion
- English speaking.
- All genders, races, and ethnicities.
- Aged greater or equal to 18 years of age.
- Ability to understand and the willingness to sign a written informed consent form.
- Diagnosed with a colon adenocarcinoma or presumed adenocarcinoma in which surgical resection is recommended.
- Have a planned surgical resection of the colon adenocarcinoma at the University of Chicago Comprehensive Cancer Center.
- Reside within 150 miles of the University of Chicago Comprehensive Cancer Center.
Exclusion
- Stage IV colon adenocarcinoma (known metastatic disease).
- Intravenous or oral antibiotic exposure within 30 days of surgery to treat an infection.
- Prebiotic exposure within 30 days of surgery.
- History of neoadjuvant chemotherapy/radiation to treat the primary colon adenocarcinoma.
- History of chemotherapy/radiation to treat a separate malignancy within the last 6 months.
- History or current ileostomy or colostomy.
- Allergy to perioperative medications (oral neomycin/metronidazole for preoperative bowel preparation, intraoperative prophylactic intravenous cefoxitin).
- Patients who are pregnant.
- Patients with a history of inflammatory bowel disease.
- Patients with a history of bariatric surgery.
- History of eating disorders.
Key Trial Info
Start Date :
February 1 2026
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
October 1 2026
Estimated Enrollment :
107 Patients enrolled
Trial Details
Trial ID
NCT07211230
Start Date
February 1 2026
End Date
October 1 2026
Last Update
December 15 2025
Active Locations (1)
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1
University of Chicago
Chicago, Illinois, United States, 60637