Status:
NOT_YET_RECRUITING
rTMS for Cerebellar Ataxia in Children
Lead Sponsor:
The University of Hong Kong
Conditions:
Cerebellar Ataxia
Eligibility:
All Genders
4-18 years
Phase:
NA
Brief Summary
Dysfunction of the cerebellum can result in cerebellar ataxia (CA), typically marked by symptoms such as movement incoordination, gait instability, articulation disorder, oculomotor and swallowing dif...
Detailed Description
To address the research gap, our study aims to use low frequency rTMS over the contra-lesional cerebellum in children with cerebellar ataxia. We aim to measure the reduction in ataxic symptoms, the im...
Eligibility Criteria
Inclusion
- Patients aged ≥ 4 years old - 18 years old fulfilling the following criteria: 1) diagnosis of cerebellar ataxia based on clinical history and neurological examination; 2) cerebellar lesion seen by MRI; 3) IQ ≥ 50 to ensure sufficient cognitive capacity for comprehending and adhering to motor training protocols.
Exclusion
- Patients will be excluded if they have: 1) Sensory ataxia with etiologies involving the peripheral nerves or posterior columns of the spinal cord, 2) Any contra-indications to rTMS, 3) Severe spasticity (defined as a score of 4 in the Modified Ashworth Scale) and contractures, 4) Uncontrollable epilepsy defined as the occurrence of seizures despite the use of at least one anti-epileptic drug (AED) in adequate dose, 5) History of Botulinum toxin A injection or upper limb casting in previous 6 months, and 6) Cerebellar ataxia resulting from genetic conditions.
Key Trial Info
Start Date :
October 1 2025
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
March 31 2028
Estimated Enrollment :
20 Patients enrolled
Trial Details
Trial ID
NCT07211490
Start Date
October 1 2025
End Date
March 31 2028
Last Update
October 8 2025
Active Locations (1)
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1
The University of Hong Kong
Hong Kong, Hong Kong, China