Status:
NOT_YET_RECRUITING
Methamphetamine Use Disorder Support in Heart Failure Pilot Study
Lead Sponsor:
University of Southern California
Collaborating Sponsors:
Los Angeles General Medical Center
Conditions:
Heart Failure
Methamphetamine Use Disorder
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
Heart failure (HF) affects over 6 million people in the US and is a major cause of both hospital admissions and death. HF has many causes and contributing factors. One of the most aggressive forms of ...
Detailed Description
Prospective, open-label, single-arm study to evaluate the feasibility and preliminary efficacy of a multidisciplinary HF clinic which integrates MUD management along with standard-of-care guideline di...
Eligibility Criteria
Inclusion
- Heart failure diagnosis meeting universal definition criteria with left ventricular ejection fraction ≤ 40%
- Active methamphetamine use and stated desire to cease (confirmed by patient self-reported history of active use and /or positive urine toxicology obtained as part of routine patient care); physician verifying patients meets criteria for MUD.
- Age 18 years or older
- Empaneled to LA General Medical Center/DHS
- Able to provide informed consent (translated consent forms will be used for non-English speakers)
Exclusion
- Polysubstance use (excluding tobacco and marijuana)
- Documented history of alcohol use disorder (DSM-5) or alcohol dependence (ICD-11). Intermittent alcohol use below these thresholds (e.g. social use) is not an exclusion.
- Cardiogenic shock requiring mechanical circulatory support at time of presentation
- Acute coronary syndrome, acute pulmonary embolism, or hemodynamically significant arrhythmia on admission
- Pregnancy
- Acute psychiatric condition requiring immediate treatment or significantly impairing their ability to provide informed consent or participate in study procedures
Key Trial Info
Start Date :
November 1 2025
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
July 31 2026
Estimated Enrollment :
50 Patients enrolled
Trial Details
Trial ID
NCT07211724
Start Date
November 1 2025
End Date
July 31 2026
Last Update
October 8 2025
Active Locations (2)
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1
Los Angeles General Medical Center
Los Angeles, California, United States, 90089
2
University of Southern California, Alfred E. Mann School of Pharmacy and Pharmaceutical Sciences
Los Angeles, California, United States, 90089