Status:
NOT_YET_RECRUITING
Post-stroke REhabilitation Start Evaluation for Reducing Vascular Events
Lead Sponsor:
University of Calgary
Conditions:
Stroke
Ischemic Stroke
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
The purpose of this research study is to better understand when to start rehabilitation therapies after acute ischemic stroke to prevent further harm to the brain and to improve outcomes for stroke su...
Detailed Description
While stroke remains the world's second leading cause of death and reduced quality of life in adults, mortality and disability have decreased over the years with advances in acute care and improvement...
Eligibility Criteria
Inclusion
- Participants with acute ischemic stroke presenting to Foothills Medical Centre meeting eligibility for intravenous thrombolysis (Tenecteplase, TNK) - ≥18 years of age presenting within 4.5 hours of symptom onset with a diagnosis of suspected acute ischemic stroke causing significant neurological disability - and/or endovascular thrombectomy (EVT).
- Age ≥18 years.
- Persistent vessel occlusion will be defined as any of the following:
- EVT treatment of medium or large intracranial vessel occlusion with a thrombolysis in cerebral infarction (TICI) score of ≤2b.
- A moderate infarct core (ASPECTS ≤5) despite TICI 3.
- 24-hour CT with evidence of hyperdense sign appropriate to clinical deficits.
Exclusion
- Comorbid conditions limiting recovery or life expectancy (e.g., significant cognitive impairment, stage IV cancer, end-stage renal disease).
- Low pre-stroke baseline functional status (mRS ≥4).
- Symptoms due to another acute neurological condition (e.g., migraine with aura, seizure) or neurological deficits secondary to metabolic/toxic derangements (e.g., hyponatremia, hypoglycemia).
Key Trial Info
Start Date :
October 15 2025
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
November 30 2026
Estimated Enrollment :
50 Patients enrolled
Trial Details
Trial ID
NCT07212738
Start Date
October 15 2025
End Date
November 30 2026
Last Update
October 8 2025
Active Locations (1)
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1
Foothills Medical Centre
Calgary, Alberta, Canada, T2N 2T9