Status:
NOT_YET_RECRUITING
Alpha tACS for Disorders of Consciousness : a Single Case Experimental Design
Lead Sponsor:
Hospices Civils de Lyon
Conditions:
Disorder of Consciousness
Eligibility:
All Genders
18-70 years
Phase:
NA
Brief Summary
BRIEF SUMMARY \* (Include a statement of the study hypothesis) Avoid all personal pronouns (Limit: 5000 characters) Disorders of consciousness (DoC) following a severe traumatic brain injury represent...
Eligibility Criteria
Inclusion
- Age 18 to 70 years
- Persistent disorder of consciousness (vegetative state/unresponsive wakefulness syndrome or minimally conscious state) according to the Coma Recovery Scale-Revised (CRS-R), lasting 3 to 12 months after traumatic brain injury at the time of the inclusion
- No evidence of exit from minimally conscious state (eMCS) according to Coma Recovery Scale-Revised (CRS-R)
Exclusion
- Active epilepsy or major pre-existing central nervous system disorders
- Craniectomy without bone flap replacement, non-healed scalp lesions, intracerebral metallic implants (except titanium), or implanted electronic devices (e.g., pacemaker)
- Contraindications to MRI (non-compatible devices, metallic fragments, recent tattoos, etc.)
- Pregnant or breastfeeding women
- Persons deprived of liberty, under psychiatric care, or not affiliated with a social security/health insurance system
Key Trial Info
Start Date :
January 1 2026
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
June 1 2028
Estimated Enrollment :
5 Patients enrolled
Trial Details
Trial ID
NCT07213869
Start Date
January 1 2026
End Date
June 1 2028
Last Update
October 9 2025
Active Locations (1)
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1
Post-Intensive Care Neurorehabilitation Unit (Service de Reeducation Post-Reanimation) in Pierre Wertheimer Neurologic Hospital
Bron, France, 69029