Status:
RECRUITING
A Study to Learn About Study Medicine Called PF-08049820 in People With Eczema
Lead Sponsor:
Pfizer
Conditions:
Atopic Dermatitis
Eczema, Atopic
Eligibility:
All Genders
18+ years
Phase:
PHASE2
Brief Summary
The purpose of this study is to learn if the study medicine (PF-08049820) is safe and effective for the treatment of atopic dermatitis (AD), also known as eczema, or atopic eczema. People with this co...
Eligibility Criteria
Inclusion
- Participants must meet the following criteria:
- Are 18 years of age or older
- Have clinical diagnosis of AD for at least 6 months prior to Day 1 and have diagnosis of AD confirmed by photographs
- Have moderate to severe AD as defined by the following at screening and baseline visits:
- Affected body surface area (BSA) greater than or equal to 10% and up to 60%;
- Validated Investigator's Global Assessment (vIGA) greater than or equal to 3;
- Eczema Area and Severity Index (EASI) greater than or equal to 16;
- AND
- Peak Pruritis Numeric Rating Scale (PP-NRS) greater than or equal to 4 at screening and a weekly average of greater than or equal to 4 at baseline visit
- Do not have a suitable prescribed medicine for AD.
- Body Mass Index (BMI) of 17.5 to 40 kg/m2 and a total body weight greater than 45 kg (100 lbs)
Exclusion
- Participants must not meet the following criteria:
- Have an infection that requires treatment
- Have other skin conditions other than AD
- Have severe uncontrolled asthma
- Regular use (more than 2 visits per week) of a tanning booth or phototherapy for AD within 4 weeks of the screening visit
Key Trial Info
Start Date :
November 20 2025
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
August 23 2027
Estimated Enrollment :
200 Patients enrolled
Trial Details
Trial ID
NCT07216027
Start Date
November 20 2025
End Date
August 23 2027
Last Update
December 5 2025
Active Locations (4)
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1
Clinical Science Institute
Santa Monica, California, United States, 90404
2
Gsi Clinical Research
Margate, Florida, United States, 33063
3
Skin Research of South Florida
Miami, Florida, United States, 33173
4
Goodlettsville Dermatology Research
Goodlettsville, Tennessee, United States, 37072