Status:
NOT_YET_RECRUITING
A Study of REGN7041 for Active Noninfectious Uveitis in Adult Participants
Lead Sponsor:
Regeneron Pharmaceuticals
Conditions:
Active Noninfectious Uveitis Affecting the Posterior Segment
Eligibility:
All Genders
18+ years
Phase:
PHASE1
PHASE2
Brief Summary
This study is researching an experimental drug called REGN7041 (also referred to as "study drug"). The study is focused on patients who have active inflammation inside of the eye without any signs of ...
Eligibility Criteria
Inclusion
- Key
- Diagnosis of non-infectious anterior, intermediate, posterior or panuveitis (For anterior uveitis, there must be evidence of inflammation affecting the posterior segment), as defined in the protocol
- Active disease at baseline, as defined in the protocol
- Part A only: Best Corrected Visual Acuity (BCVA) of ≤65 and \>10 Early Treatment Diabetic Retinopathy Study (ETDRS) letters (Snellen equivalent of worse than or equal to 20/50 and better than 20/630) at the screening visit and on day 1
- Part B only: BCVA of \<75 and \>10 ETDRS letters (Snellen equivalent of worse than 20/32 and better than 20/630) at the screening visit and on day 1
- Key
Exclusion
- BCVA of ≤30 ETDRS letters (Snellen equivalent of 20/250 or worse) at the screening visit and/or on day 1
- Intraocular Pressure (IOP) \<5 mm Hg at the screening visit and/or on day 1
- IOP \>25 mm Hg on day 1. Participants are permitted to take IOP-lowering eye drops
- Confirmed or suspected infectious uveitis, as defined in the protocol
- NOTE: Other Protocol-Defined Inclusion/Exclusion Criteria Apply
Key Trial Info
Start Date :
December 15 2025
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
April 28 2028
Estimated Enrollment :
72 Patients enrolled
Trial Details
Trial ID
NCT07218770
Start Date
December 15 2025
End Date
April 28 2028
Last Update
October 20 2025
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