Status:
ENROLLING_BY_INVITATION
Radiation Therapy (RT) for Parkinson's Disease (PD)
Lead Sponsor:
Mayo Clinic
Conditions:
Parkinson's Disease
Eligibility:
All Genders
45-70 years
Phase:
NA
Brief Summary
The purpose of this study is to investigate the use of ultra-low, anti-inflammatory doses of radiation therapy (RT) for the treatment of Parkinson's Disease (PD). In this study, the TrueBeam LINAC uti...
Eligibility Criteria
Inclusion
- Inclusion Criteria
- Age ≥ 45 and ≤ 70 years
- Diagnosis of Parkinson's disease by a Movement Disorder Neurologist
- Confirmation of unilateral Parkinson's disease by Dopamine Transporter (DaT) scan
- A score of 2 or less on the modified Hoehn and Yahr scale
- ECOG Performance Status (PS) ≤ 2 (Appendix I).
- No known genetic causes or predisposition to Parkinson's disease or related diseases.
- Ability to complete questionnaires, neurological exam, and follow-up imaging independently or with assistance
- Ability to provide written informed consent
- Willing to provide mandatory blood samples for correlative research purposes
- Willing to return to enrolling institution for follow-up
- Exclusion Criteria
- Concomitant dementia diagnosis or concerns of other memory disorder
- Parkinson's Disease medication changes within the last 3 months
- Receipt of radiation therapy for Parkinson's Disease outside Mayo Clinic, Rochester
Exclusion
Key Trial Info
Start Date :
December 1 2025
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
October 1 2027
Estimated Enrollment :
20 Patients enrolled
Trial Details
Trial ID
NCT07218952
Start Date
December 1 2025
End Date
October 1 2027
Last Update
November 19 2025
Active Locations (1)
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1
Mayo Clinic in Rochester
Rochester, Minnesota, United States, 55905