Status:
NOT_YET_RECRUITING
Primary Prophylaxis of Clostridioides Difficile Infection With Oral Vancomycin
Lead Sponsor:
University of Maryland, Baltimore
Collaborating Sponsors:
University of Maryland, Baltimore Washington Medical Center
Conditions:
Clostridioides Difficile
Vancomycin Resistance Enterococcus Faecium
Eligibility:
All Genders
65-100 years
Phase:
PHASE2
PHASE3
Brief Summary
The purpose of this study is to evaluate the ability of oral vancomycin in preventing Clostridioides difficile infection (CDI) in patients that are simultaneously receiving antibiotics. Participants ...
Detailed Description
This research study is being conducted to evaluate the feasibility of prescribing oral vancomycin in preventing CDI in patients who are receiving concomitant systemic antibiotics. There are two group...
Eligibility Criteria
Inclusion
- Age 65 years or older
- Receive systemic antibiotics in the last 90 days
- Hospitalized anywhere in the last 90 days
- History of C diff colonization without history of C diff colitis (infection)
- Provide informed consent
- Read and understand the English language
- Not current taking probiotics
- Lack of allergy or contraindications to receive vancomycin
- Ability to take oral medications
- Not receiving medications that can be used to treat or prevent C diff
Exclusion
- Age 64 years or younger
- Has not received systemic antibiotics in the last 90 days
- Has not been hospitalized in the last 90 days
- History of C diff colonization with a history of C diff colitis (infection)
- Not provided informed consent
- Cannot read and understand the English language
- Currently receiving probiotics
- Allergy or contraindications to receive vancomycin
- Unable to take oral medications
- Receiving medications that can be used to treat or prevent C diff
Key Trial Info
Start Date :
March 1 2026
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
December 31 2027
Estimated Enrollment :
200 Patients enrolled
Trial Details
Trial ID
NCT07221708
Start Date
March 1 2026
End Date
December 31 2027
Last Update
January 7 2026
Active Locations (1)
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1
University of Maryland Baltimore Washington Medical Center
Glen Burnie, Maryland, United States, 21061