Status:
RECRUITING
German Dementia Registry
Lead Sponsor:
RWTH Aachen University
Collaborating Sponsors:
Eisai GmbH
Lilly Deutschland GmbH Germany
Conditions:
Dementia Disorder
Eligibility:
All Genders
18+ years
Brief Summary
The German Dementia Registry (DEMREG) is a large-scale national prospective biomarker-based study for cognitive impairment and dementia, providing an integrated clinical research platform for research...
Detailed Description
The aim of the German Dementia Registry is to prospectively collect longitudinal real-world data on all consenting patients diagnosed in clinical routine with Subjective Cognitive Decline (SCD), Mild ...
Eligibility Criteria
Inclusion
- Inclusion Criteria for Patient:
- Ability of the participant and/or his/her legally authorized representative (e.g., spouse or legal guardian), as appropriate and applicable, to understand the purpose and risks of the register and provide signed and dated informed consent and authorization to use protected health information (PHI) in accordance with national and local privacy regulations.
- Participating patients must have a diagnosis of SCD, MCI or early dementia of different etiology (i.e. Alzheimer's Disease, Frontotemporal Dementia, Parkinson's Disease, Lewy-Body Dementia, Progressive Supranuclear Palsy, Corticobasal Degeneration, Normal Pressure Hydrocephalus, Major Depression; Vascular Dementia; TDP-43 associated limbic encephalopathy (LATE), Mixed Dementia AD + VaD, Prion-Associated Dementia) together with biomarkers such as cerebrospinal fluids (CSF) amyloid beta 1-42, amyloid beta 1-40, amyloid beta 1-42/amyloid beta 1-40 ratio, total tau and phosphorylated tau, amyloid or tau imaging.
- At least 18 years of age.
- Inclusion Criteria for family member:
- At least 18 years of age.
- Patient was included in the registry
- Family member is strongly involved to the patient's life according to the patient's statement
- Ability of the participant, as appropriate and applicable, to understand the purpose and risks of the register
Exclusion
- Exclusion Criteria for Patient:
- Unwilling to provide informed consent.
- No available biomarkers such as cerebrospinal fluids (CSF) amyloid beta 1-42, amyloid beta 1-40, amyloid beta 1-42/amyloid beta 1-40 ratio, total tau and phosphorylated tau, amyloid or tau imaging.
- Exclusion Criteria for family member:
- Unable or unwilling to provide informed consent.
Key Trial Info
Start Date :
May 16 2022
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
December 1 2099
Estimated Enrollment :
5000 Patients enrolled
Trial Details
Trial ID
NCT07433010
Start Date
May 16 2022
End Date
December 1 2099
Last Update
February 25 2026
Active Locations (24)
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1
Heidelberg University Hospital
Heidelberg, Baden-Wurttemberg, Germany, 69120
2
ZI Mannheim
Mannheim, Baden-Wurttemberg, Germany, 68159
3
University Hospital Tübingen
Tübingen, Baden-Wurttemberg, Germany, 72076
4
Ulm University Hospital
Ulm, Baden-Wurttemberg, Germany, 89070